Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors - Springer
Abstract
For centuries the plants
Cannabis sativa and
Cannabis indica (commonly known as
marijuana) have been used for recreational, religious, and medicinal purposes across diverse cultures. The first recorded attributes of
Cannabis were on its potent therapeutic actions, which included analgesic, sedative, and anticonvulsant effects. In the 1930s
Cannabis extracts were one of the most commonly prescribed medicines of the US pharmacopeia. Unfortunately, the early criminalization of the use of
Cannabis resulted in a near 35-year stall in scientific research aimed at understanding and optimizing the therapeutic potential of its extracts. It was the isolation and chemical characterization of ∆
9-tetrahydrocannabinol (THC) in 1964 as the first bioactive ingredient produced by
Cannabis that revived the scientific community’s interest in further understanding and optimizing the unique therapeutic properties of phytocannabinoids (phyto-CB) (Mechoulam and Gaoni 1967)
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