PLOS ONE: Role of Endocannabinoids and Cannabinoid-1 Receptors in Cerebrocortical Blood Flow Regulation
"n conclusion, our study indicates that under resting physiological conditions CB1-receptor mediated mechanisms have limited tonic influence on the systemic and cerebral circulation. In agreement with previous studies investigating the systemic effects of intravenous administration of anandamide (reviewed in [4], [98]), we found that acute enhancement of EC levels by inhibition of cannabinoid cellular reuptake leads to transient increase of blood pressure followed by more sustained hypotension, as well as to suppression of the respiration; and that these responses, except for the initial hypertension, are mediated by CB1-receptors. Most importantly, our data suggest that the EC system and CB1-receptors play an important role in the regulation of the cerebral circulation during hypoxia and hypercapnia and may potentially be involved in the autoregulation of CBF."
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