13. Cannabinoids as antioxidant: An overview

13. Cannabinoids as antioxidant: An overview'

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37/661 (2), Fort P.O.

Trivandrum-695 023

Kerala, India

Medicinal Plants as Antioxidant Agents: Understanding Their Mechanism of Action and Therapeutic

Efficacy, 2012: 289-312 ISBN: 978-81-308-0509-2 Editor: Anna Capasso

13. Cannabinoids as antioxidant:

An overview

Claudia Grimaldi, Mariella Caputo, Mario Felice Tecce and Anna Capasso

Department of Pharmaceutical and Biomedical Sciences, University of Salerno

84084-Fisciano, Italy

Abstract. Cannabinoids have been found to have antioxidant

properties, unrelated to NMDA receptor antagonism. This new

found property makes cannabinoids useful in the treatment and

prophylaxis of wide variety of oxidation associated diseases, such

as ischemic, age-related, inflammatory and autoimmune diseases.

The cannabinoids are found to have particular application as

neuroprotectants, for example in limiting neurological damage

following ischemic insults, such as stroke and trauma, or in the

treatment of neurodegenerative diseases, such as Alzheimer’s

disease, Parkinson’s disease and HIV dementia. The aim of this

chapter was to understand the mechanism of antioxidant action and

therapeutic efficacy of cannabinoids